Evaluation of Vascular Complication and Lack of Glycemic Control as Factors in the Development of Ovarian Cancer in Female Nigerian Type 2 Diabetic Population

Abstract

Hypertension and diabetes are important medical conditions that are responsible for a significant number of deaths globally. Therefore, the objective of this study was to assess the human epididymis protein-4 in patients with untreated and treated uncomplicated and complicated type 2 diabetes with hypertension at a teaching hospital in Ido-Ekiti, Ekiti State, Nigeria using blood samples and appropriate standard techniques. The results (mean ± SD) obtained showed that the glucose level (mmol/L) in untreated DM, Treated DM and Control was 9.13±1.51, 5.05±0.84 and 4.71±0.81, while HE4 (nmol/L) was 59.52±9.85, 30.49±5.12 and 24.78±4.18 respectively. Furthermore, the glucose (mmol/L) level in untreated DM/HTN subjects and treated DM/HTN subjects was 10.02±3.46 and 4.99±1.04, while HE4 (nmol/L) was 103.33±34.58 and 50.32±5.02 respectively. In conclusion, this research found that HE4 was significantly increased (p<0.05) in T2DM subjects with uncomplicated and complicated type 2 diabetes with hypertension compared to control and therefore it can be considered that ovarian cancer can be associated with type 2 diabetes and HE4 can be used as a marker of early detection in both uncomplicated and complicated type 2 diabetes.