Effects of Aqueous Leaf Extract of Kalanchoe pinnata on Bifenthrin-Induced Injury in the Lungs of the Adult Wistar Rat

Abstract

The aim of this study was to investigate the effects of aqueous leaf extract of Kalanchoe pinnataon Bifenthrin-induced injury in the lungs of adult Wistar rats. The 30 adult Wistar rats weighing between 250g and 280g that were used in this research were divided into 5 groups of 6 rats per group. The haematological outcome showed that Bifenthrin caused some derangements in haematological parameters especially lymphocytes and basophils, haemoglobin and red blood cells with associated reticulocytosis. Histologically, marked bronchiolar dilation, marked alveolar dilatation and severe vascular ulceration were observed in the rats exposed to bifenthrin only. Kalanc hoepinnata showed no negative effects on the histology of the lungs as the alveoli and the bronchial artery of the rats treated with Kalanchoe pinnata extract were found to be histologically normal when compared with the control. In conclusion, Kalanchoe pinnata has ameliorative effects against bifenthrin-induced injury in the lung of Wistar rats and its effect is inversely proportional to dosage. It is more potent at low doses.