Synthesis of Flavonoids Derivatives using Polar and Non-Polar Extract of Red Onion Skin (Quercetin) with Cashew Nut Shell Liquid

Abstract

Red Onion skin extract and Cashew nut shell liquid has been considered as one of the best antioxidant and anti-inflammatory precursors, as it contains various polyphenols and important flavonoids. In this research, flavonoid derivatives were successfully synthesized from polar and non-polar extract of red onion skin, non-polar extract of cashew nut shell liquid and a combination of the onion skin extracts and cashew nut shell liquid.  In this process, crude red onion skin extract was obtained using potassium carbonate via maceration process and acetone via soxhlet extraction. Cashew nut shell liquid was extracted using acetone via soxhlet extraction. The synthesis was carried out via the Williams ether synthesis using 1,2-dibromoethane in the presence of a base catalyst. FTIR of the products confirmed its modification. From the result, it can be concluded that the non-polar extract performed better than the polar extract. Hence for further studies, non-polar solvents should be considered for extraction.