Evaluation of Protective Potential of Aqueous Seed extract of Ripe Fruits of Carica papaya on Cyanide Induced Kidney Damage in Male Wister Rats

Abstract

This study aimed to evaluate the protective potential of aqueous seed extract of ripe Carica papaya fruits on cyanide induced kidney damage in male Wister rats using 24 male rats divided into five groups. The animals were sacrificed at the end of the experimental period and serum and kidney were harvested for biochemical and histological analysis following standard procedures. Estimation of kidney function markers such as creatinine and urea and assessment of electrolytes of toxicological relevance; sodium ion, potassium ion, bicarbonate ion and chloride ion were carried out. The study revealed that cyanide stimulated alterations in kidney function makers: urea, creatinine and serum electrolytes. The result indicated that aqueous seed extract of Carica papaya fruits significantly increase Urea, creatinine, Cl^-, HCO^3-, K⁺ and Na⁺ activities in the rats induced with cyanide when compared with the positive control. However, the concentrations were significantly decreased in the treated groups when compared with the groups induced with cyanide. Histological analysis showed cyanide induced structural distortions of the kidney tissues. Treatment with Carica papaya seed extract was able to mitigate these damages. This study indicates that aqueous seed extract of ripe fruits of Carica papaya possesses nephro-protective properties and can be used as an antidote for cyanide poisoning.