Identification and Antifungal Susceptibility Profiles of Yeast Urogenital Tract Infection among Women in Benin City, Nigeria

Abstract

The incidence of candida infections is on the increase globally, with laboratories not performing speciation and susceptibility testing routinely. This study aims to speciate and determine the susceptibility profile of yeast isolates recovered from urogenital specimens. A total of 115 female participants with signs and symptoms of urogenital tracts infection attending various clinics in University of Benin Teaching Hospital Benin City, Nigeria were recruited for this study. A total of 55 mid-stream urine and 60 high vaginal swabs and or endocervical swabs were collected from the participants and processed to recover yeast isolates. The yeast isolates were identified and susceptibility test performed using standard techniques. The prevalence of candiduria - 54.55% and vaginal candidiasis - 63.33%, did not differ significantly (P = 0.4426). Age did not significantly affect the prevalence of candiduria and vaginal candidiasis (P = 0.0525 and P = 0.2194, respectively). Candida albicans was the most prevalent yeast isolate recovered from urine and genital specimens. Amphotericin B and nystatin were the most active antifungal agents while fluconazole was the least active. High prevalence of yeast urogenital tract infections was observed in this study.