Alanine Aminotransferase and Aspertate Aminotransaminase Activities in Wistar Rats Fed with Musa paradisiaca (Plantain) Stem Pulp in Aluminium Chloride Induced Hepatic Oxidative Stress

Abstract

In this study, the effect of Musa paradisiaca (plantain) stem pulp on aluminium chloride (AlCl₃) induced hepatotoxicity was studied. Fifteen (15) healthy female wistar rats after acclimatization for two weeks were randomly distributed to three (3) groups, with five (5) rats in each group. Group 1 served as control and received as control pelletized growers feed and distilled water throughout the experiment (14 days). Group 2 received 100mg/kg/body weight (b.w.) of aluminium chloride and was fed with pelletized growers feed and distilled water for 14 days and group 3 received 100mg/kgb.w of aluminium chloride and 2mL/kg of the juice gotten from M. paradisiaca and were also allowed free access to feed and water ad libitum for 14 days. Blood samples were collected via cardiac puncture and analyzed for AST, ALT, MDA and SOD. Results revealed that there was a significant increase in AST and ALT levels respectively from 67.83±1.39 to 173.40±0.81 and 43.73±1.00 to 128.24±0.68 after treatment with AlCl₃ compared to control while administration of M. paradisiaca extract ameliorated the adverse effects of AlCl₃ when compared to AlCl₃ treated groups from 173.40±0.81 to 72.40±1.71 and 128.24±0.68 to 45.83±1.22 respectively. There was a significant decrease (P<0.05) in SOD level from 6.04± 0.49 to 2.56±0.86 of AlCl₃ compared to control and a significant increase (P<0.05) from 2.56±0.86 to 6.00±1. 56 in SOD level was observed in M. paradisiaca treated groups when compared to AlCl₃ treated group. It was also observed that there was a significant (P<0.05) from 401.09±0.10 to 1207.98±1.39 in MDA level after treatment with AlCl₃ compared to control while there was a significant decrease (P<0.05) from 1207.98±1.39 to 388.83±31.15 in MDA level of M. paradisiaca treated groups when compared to the AlCl₃ treated groups. It was observed that M. paradisiaca showed a mitigating effect on aluminium chloride-induced hepatotoxicity and thus justifying the hepatoprotective property of M. paradisiaca.