Effects of Phoenix dactylifera Tree Fruit Extract on Cadmium Induced Renal Damage in Adult Wistar Rats

Abstract

The objective of the study is to investigate the ameliorative potential of date palm tree (Phoenix dactylifera) fruit on cadmium induced kidneydamage in adult Wistar Rat using standard technique. Thirty (30) adult Wistar rats were divided into six groups of five rats per group.  Group A (control); Group B (0.1ml/kg body weight of cadmium); Group C (200mg/kg body weight of Phoenix dactylifera); Group D (600mg/kg body weight of Phaoenix dactylifera); Group E (0.1ml/kg body weight of cadmium and 200mg/kg body weight of Phoenix dactylifera); Group F (0.1ml/kg body weight of cadmium and 600mg/kg body weight of Phoenix dactylifera). Treatments were administered once daily for 30 days. After day 30, biochemical and histopathological studies were conducted to appraise oxidative stress and renal toxicity. Serum levels of creatinine, urea, catalase (CAT) and superoxide dismutase (SOD) were quantified. Animals treated alone with cadmium (Group B), showed significant (P < 0.05) increase in serum urea, serum creatinine and CAT, SOD levels statistically. Treatment of rats with Phoenix dactyliferaalongside cadmium (Group E and F) showed significant (P < 0.05) improvement in renal function and restoration of biochemical parameters mentioned earlier. Histopathological findings confirm these conservations. Therefore, the administration of aqueous extract of Phoenix dactylifera has protective effect on cadmium-induced renal toxicity and oxidative stress in wistar rats which can be attributed to Phoenix dactylifera antioxidant activity.