Chemo-Protective Effects of Dl-Limonene Unaided and in-Blend with 6-Methyleneandrosta-1, 4-Diene-3, 17-Dione on N-Nitroso-N-Methylurea and Estrogen Sulfotransferase Breast Cancer-Induced Albino Female Rat

Abstract

Breast cancer is a serious prime hassle commonly diagnosed in women worldwide and it is currently the leading cause of cancer-related mortality. In N-nitroso-N-methylurea (NMU) and estrogen sulfotransferase (EST) breast cancer-induced female rat, the study evaluates the chemo-protective possibilities of DL-limonene (1:1) and its combination with 6-Methyleneandrosta-1, 4, Diene- 3, 17-Dione using standard techniques. Amongst others, data obtained reveals mild areas of clogged blood vessels and pulmonary inflammation revealed in the histopathology section. Interestingly, it's possible that DL-limonene alone at a concentration of 10% could be an effective breast cancer treatment. The findings also revealed that combining DL-limonene with 6-ADD at 5% and 12.5mg/kg could reduce the risk of toxicity associated with higher chemotherapeutic dosages in long-term treatment. Furthermore, at a modest dose, this combination may increase the use of aromatase inhibitors in premenopausal women. Despite the medicinal and therapeutic benefits of DL-limonene, it is best to take it in moderation due to its possible harmful effects on the blood vessels.