Protective Activity of Chloroform Extract of Gomphrena celosioides Leaves (Amaranthaceae) on Some Biochemical Indices in Aspirin-induced Wistar Rats

Abstract

The protective activities of Gomphrena celosioides on Aspirin-induced alterations in biochemical markers were investigated in the kidney and liver of Wistar rats. Serum creatinine and blood urea nitrogen concentrations were assessed to determine biochemical alteration in the kidney, while total bilirubin and direct bilirubin concentrations were assessed to determine biochemical alteration in the liver. Four groups of rats were used.  In group 1, the control rats were treated with 1% Gum Acacia solution. Group 2 was treated with Aspirin at 200 mg/kg b.w alone. Group 3 was treated with Aspirin at 200 mg/kg b.w and G. celosioides at 500 mg/kg b.w while Group 4 received G. celosioides at 500 mg/kg b.w. All the administration and treatment lasted for 7 days. A significant increase (P < 0.05) in the concentrations of serum creatinine (69.60 ± 4.16 mg/dl), total bilirubin (38.36 ± 5.33 mg/dl), direct bilirubin (15.17 ± 2.22 mg/dl) and blood urea nitrogen (27.05 ± 4.85 mg/dl) was observed in the rats treated with 200 mg/kg b.w aspirin. There was significant decrease (P < 0.05) in the concentrations of creatinine, total bilirubin, direct bilirubin, and blood urea nitrogen in the rats in group 3 (59.58 ± 2.972 mg/dl, 31.41 ± 6.22 mg/dl, 11.09 ± 1.40 mg/dl, 13.12 ± 0.67 mg/dl) and in rats in group 4 (53.2 ± 1.16 mg/dl, 32.19 ± 3.36 mg/dl, 13.49 ± 4.06 mg/dl, 10.63 ± 3.16 mg/dl) when compared with  rats in group 2. While there was no significant (P < 0.05) difference when compared with group 1 (control) (52.20 ± 3.25 mg/dl, 30.75 ± 1.23 mg/dl, 12.46 ± 1.12 mg/dl, 7.29 ± 2.07 mg/dl).  The results reveal that G. celosioides can provide significant protection against biochemical alterations in aspirin-treated rats.