Synergistic Effect of Ethanolic Extract of Phyllantus Muellerianus and Eremomastax Speciosa Leaves on Lipid Profile of Wistar Rat

Abstract

The study investigated the synergistic effect of ethanolic extract of Eremomastax speciosa and Phyllantus muellerianusleaves on the lipid profile of Wistar rats. The Wistar rats were assigned into two groups of 10 animals each; the control was given normal rat pellet and water, while the experimental group was given the mixture of the ethanolic plant extracts at 200mg/kg body weight, by orogastric intubations once daily. The animals were fed for 3weeks (21 days) during which anthropometric measurement and data were collected. Twelve hours after the feeding and administration of both plants extract, the animals were anesthetized under chloroform vapor and then dissected. Blood samples were collected from the heart by cardiac puncture into plain tubes and taken to the laboratory for analysis. The phytochemical result indicates that the extract contains a high amount of flavoniods and alkaloids; a moderate amount of saponins, tannins, and polyphenols with a mild amount of glycosides. The result of the study shows a mean significant decrease in the TC level and LDL-C level; an abnormal increase in the levels of TG, VLDLC, and an abnormal decrease in HDL-C between the experimental and control group at a probability level of p<0.05. The phytochemical result indicates that the plant can be used to manage many health conditions like Stomach troubles, headaches, jaundice, and anemia (Obenet al., 2006). While the overall result of the study reveals that the administration of both extracts has both hypolipidemic effects and hyperlipidemic effects on the lipid profile levels correlate with cardiovascular disease.