Identification and Characterization of Bioactive Components in Datura stramonium Leaves: an insight into Drugs Discovery

Abstract

Medicines from plants help in treating ailments, but to utilize them effectively in the management of diseases requires the identification of potent phytochemicals relative to conventional drugs. These phytochemicals are compared with synthetics drugs in line with their treatment regimen. An investigation was designed to identify, and characterized the different phytochemicals in Datura stramonium (Jimson weed) leaves and compared them with conventional or standard drugs. The identified phytochemicals were blasted on the drugs bank website to find their correlation and relativity. GC/MS technique was used to analyze the phytochemicals. The results showed 80 different phytochemicals belonging to several categories of phytochemicals - alkaloids, flavonoids, terpenoids, saponins, amine, and steroids. The flavonoid class had - 1.24% of 5H-Dibenzo[c, f][1, 2] diazepine, 3, 8 dichloro-6,11-dihydro, at 3.702 RT, Alkaloid class has – 2.98% 2,6-Dibromobenzoquinone was detected at 4.403 RT, steroid – 2.98% Acetanilide, 2-chloro-4'-nitro- at 4.403 RT was obtained and Terpene – 2.05% of Methyl-beta.-[N-methylanilino]acrylate was detected at 4.719 RT, respectively. Most of the identified phytochemicals matched with synthetic drugs and confirmed the purpose of their applicability in traditional medicine. Considering the presence of numerous components and their correlation with conventional drugs, one can infer that this plant species has a good therapeutic application and can be utilized for health benefits.