Effects of Cadmium Exposure on Bone and Kidney Alkaline Phosphatase Activity and Acid Phosphatase Activity in Testis and Prostate Gland in the Male Rat

Abstract

This paper examines the effects of varying doses of cadmium on bone and kidney alkaline phosphatase and on testis and prostate acid phosphatase after 4 weeks of administration to separate groups of rats. Relative to the cadmium-free control rats femur bone alkaline phosphatase activity was significantly (P<0.05) elevated in rats exposed to 2 mg cadmium /kg body weight and in those exposed to 3 mg/kg. Compared to control rats kidney alkaline phosphatase activity was also statistically significantly (P<0.05) elevated in separate groups of rats exposed to 1, 2 and 3 mg cadmium/kg body weight. Prostatic acid phosphatase activities in the testis and prostate were significantly (P<0.05) decreased in the groups of rats separately exposed to 1, 2 and 3 mg cadmium/kg. At the highest dose nonprostatic acid phosphatase activity increased significantly (P<0.5) in testis and prostrate. In serum at the highest dose nonprostatic acid phosphatase decreased while the prostatic isoform and alkaline phosphatase increased significantly (P<0.05). Our results indicate that cadmium enhances the activities of alkaline phosphatase in the bone and kidney, which of nonprostatic acid phosphatase in the testis and prostate but lowers the activity of the prostatic isoform in both.


(Journal of Applied Sciences & Environmental Management: 2002 6(1): 9-13)