Anti-inflammatory Activity of Methanoilc and Ethanolic Extracts of Citrus sinensis peel (L) Osbeck on Carrageenan induced Paw Oedema in Wistar rats

Abstract

Aqueous ethanoic and methanolic extracts of Citrus Sinensis Peel were investigated for antiinflammatory activity in carrageenan induced paw oedema in wistar rats, and compared to a positive control drug, Indomethacin. These extracts were given(IP) in a concentration of 20, and 70mg/kg with extract with a concentration whichshowed maximum(95%) inhibition on carrageenan induced rat paw oedema. The effect was significantly higher than that of the standard drug indomethacin (93%).Methanol extract with a concentration of 40mg/kg produced 95% inhibition, which was also high as compared to the standard drug. Ethanolic extracts with doses of 20mg/kg and 40mg/kg produce less percentage of inhibition as compared to the standard drug Indomethacin. 

Key words: Citrus Sinensis, Anti-inflammation, Carrageenan, Peels, anti-inflammatory, ethanolic extract.