Synthesis, characterization and biological activity studies of mixed paracetamol- ascorbic acid metal complexes

Abstract

Mixed ligand-metal complexes of Paracetamol and Ascorbic acid were synthesized using FeCl₂.4H₂O, CuCl₂.2H₂O, NiCl₂.6H₂O, CoCl₂.6H₂O and ZnSO₄ salts based on two concentrations (3mmol and 5mmol). The complexes were characterized using some physical techniques such as melting point, solubility, conductivity measurement and spectroscopic analyses such as UV-Visible spectroscopy, Atomic absorption spectroscopy, and Infrared spectroscopy. Based on the physical and spectroscopic results, the coordination of the metal was through the phenolic oxygen and carbonyl oxygen in paracetamol while it was through the carbonyl oxygen and C-2 hydroxyl group in ascorbic acid. The complexes were also screened for their antimicrobial activities against some isolates of Enterococcus faecalis, Staphylococcus aureus, Clostridium difficile, Klebsiella sp., Helicobacter pylori.

Keywords: Metal, Mixed ligand-metal complexes, Paracetamol, Ascorbic acid, Isolates.