Synthesis and spectroscopic analysis of Schiff Bases of Imesatin and Isatin derivatives

Abstract

A series of new Schiff bases of Imesatin and Isatin derivatives which have been previously prepared from the reaction of Hydrazine monohydrate, p-phenylenediamine and 4,4- diaminodiphenylmethane with Isatin were reported. The compounds were characterized by elemental analyses, UV-visible, Infrared and Nuclear Magnetic Resonance (¹H NMR and ¹³C NMR) spectroscopic analyses. The synthesized Schiff bases were obtained in moderate to excellent yields between 55.3 – 89.3%. Infrared spectra of all synthesized compounds contain the characteristic azomethine linkage (-CH=N) between 1580 – 1630 cm^-1 and the N–H of the Isatin ring signals between δ 8.32 – 10.68 ppm in their ¹H NMR spectra. The present work affords reaction pathway that is efficient and operational simplicity for the synthesis of Schiff bases derivatives.

Keywords: Schiff bases, isatin, imesatin, spectroscopic analysis, biological activity