Antidiabetic and Plasma Endogenous Antioxidant Activity of alstonia boonei in Alloxan-Induced Male Diabetic Rabbits

Abstract

Alstonia boonei is a well-known plant of medicinal value but its effect on endogenous plasma antioxidant in diabetes remains unknown. Thus, need to investigate the effects of the methanolic extract of the plant on plasma bilirubin and uric acid level in alloxan induced diabetes rabbits. Twenty five rabbits divided into five groups of four rabbits each were used. There was a significant change in the levels of total bilirubin and uric acid in the plasma of treated groups as compared with both non diabetes and untreated diabetes group, while conjugated bilirubin level was relatively unchanged in the treated group. This work clearly indicates that methanolic extract of Alstonia boonei stem bark is effective in the management of diabetes as well as restoration of lost endogenous plasma antioxidants experienced in diabetes mellitus.