Article Sidebar
Published:
Aug 2, 2023Keywords:
Article Details
This work is licensed under a Creative Commons Attribution 4.0 International License.
Open access articles published in the Journal of Agriculture, Science and Technology are under the terms of the Creative Commons Attribution (CC BY) License which permits use, distribution and reproduction in any medium, provided the original work is properly cited. The CC BY license permits commercial and non-commercial re-use of an open-access article, as long as the author is properly attributed.
Copyright on any research article published in the Journal of Agriculture, Science and Technology is retained by the author(s). The authors grant the Journal of Agriculture, Science and Technology with a license to publish the article and identify itself as the original publisher. Authors also grant any third party the right to use the article freely as long as its original authors, citation details and publisher are identified.
Use of the article in whole or in part in any medium requires proper citation as follows:
Title of Article, Names of the Author, Year of Publication, Journal Title, Volume (Issue) and page. Links to the final article on the JSRE website are encouraged.
The Creative Commons Attribution License does not affect any other rights held by authors or third parties in the article, including without limitation the rights of privacy and publicity. Use of the article must not assert or imply, whether implicitly or explicitly, any connection with, endorsement or sponsorship of such use by the author, publisher or any other party associated with the article.
For any reuse or distribution, users must include the copyright notice and make clear to others that the article is made available under a Creative Commons Attribution license, linking to the relevant Creative Commons web page. Users may impose no restrictions on the use of the article other than those imposed by the Creative Commons Attribution license.
To the fullest extent permitted by applicable law, the article is made available as is and without representation or warranties of any kind whether express, implied, statutory or otherwise and including, without limitation, warranties of title, merchantability, fitness for a particular purpose, non-infringement, absence of defects, accuracy, or the presence or absence of errors.
Main Article Content
The effects of prenatal exposure to varying doses of pantoprazole on the maternal and fetal outcomes in albino rats (rattus norvegicus)
Abstract
Pantoprazole is a proton pump inhibitor used in the management of hypergastric secretions and gastroesophageal reflux during pregnancy. However, its prenatal effects on maternal and fetal outcomes are not well reported when administered at varying doses and at different gestational periods. A post-test-only experimental study design was adopted in conducting this study. A sample size of 30 female albino rats was used for the study. The 30 albino rats were grouped into two broad study categories: 3 control rats and 27 treatment rats. The 27 treatment rats were subdivided into three study groups of nine rats each according to the doses administered as follows: 9 low-dose rats, 9 medium-dose rats, and 9 high-dose rats The nine rats assemblies were further divided up into three subgroups, each of three rats, according to the time of exposure, as follows: three rats for trimester one, three rats for trimester two, and three rats for trimester three. Daily maternal weights were recorded every morning, and then at gestation day 20, all animals were humanely sacrificed and the fetuses harvested. Continuous data included the maternal and fetal weights, and discrete data included the litter sizes, number of devoured fetuses, resorbed glands, and number of embryolithalities. Data was recorded, coded, and entered in the computer using MS Excel spreadsheets version 13, and analyzed using the SPSS programme for Windows version 25 (one-way Analysis of Variance (ANOVA) followed by Tukey’s post hoc multiple comparisons test). The results were expressed as means ± standard error of the mean (SEM). Results with a P < 0.05 were considered significant in the study. This study observed that pantoprazole, at high doses, was associated with a decrease in the mean maternal weight gain, reduced litter sizes with increased numbers of resorbed endometrial glands, and devoured fetuses.
