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Étude de la Cinétique d’adsorption des molécules anti paludéennes par les résines
Abstract
Objectives: This paper presents experimental results of static and dynamic adsorption of molecules of chloroquine sulfate by DOWEX 50 W, with the aim of proposing a technique to purify the blood content of certain drugs overdose in the body. Methodology: This study is a model of in vitro experiments. The dynamic adsorption simulates the elimination of drugs from blood, and the static adsorption simulates the elimination of drugs from stomach. Chloroquine adsorption tests were conducted by different resins to determine which has the best adsorptive as regards chloroquine. The influence of different parameters (mass of adsorbent, initial concentration, temperature, pH, flow rate) on the adsorptive resins was also studied. Results: The adsorption Kinetics of this drug depends on the balance between adsorbed and free substance in the solution. The influences of initial concentration (Co) of the drug, the mass of the resin, the temperature and the pH of the solution have been evaluated. The quantities of adsorbed chloroquine sulfate decreases. The different results obtained, in this in vitro modeling, can confirm the probable role of the resin in the elimination of a drug from blood, stomach or duodenum.
Key words: modelisation, dynamic adsorption; chloroquine sulfate; resin DOWEX 50W; Kinetic constant
J. Appl. Biosci. 2013
Key words: modelisation, dynamic adsorption; chloroquine sulfate; resin DOWEX 50W; Kinetic constant
J. Appl. Biosci. 2013
