Article Sidebar
Published:
Aug 29, 2023Keywords:
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Submission of a paper for publication implies the transfer of the copyright from the author(s) to the publisher upon acceptance. Investigational Medicinal Chemistry and Pharmacology is therefore the copyright holder after publication of an article, and published articles should not be used for commercial purpose without the written consent of the Editor-in-Chief.
Main Article Content
Anti-staphylococcal activity and antibiotic-modulating effect of Olax subscorpioidea, Piper guineense, Scorodophloeus zenkeri, Fagara leprieurii, and Monodora myristica against resistant phenotypes
Abstract
Background: The development of new drugs from plants seems to be an interesting alternative approach to overcoming microbial resistance. This study aims to investigate the anti-staphylococcal and antibiotic-potentiating activity of methanolic extracts of five Cameroonian dietary plants namely Piper guineense, Fagara leprieurii, Olax subscorpioïdea, Monodora myristica and Scorodophloeus zenkeri against a panel of multidrug resistance (MDR) Staphylococcus aureus clinical isolates.
Methods: All antibacterial assays were done by broth microdilution method.
Results: Our results revealed that the studied extracts displayed antibacterial activities with minimal inhibitory concentration (MIC) values ranging from 256 to 2048 µg/mL. Seeds extract of F. leprieurii (FLS) showed the most extensive antibacterial activity, with an inhibitory spectrum of 96% of the tested bacterial strains. The lowest MIC value of 256 µg/mL was obtained with extracts of Piper guineense seed (PGS) and Scorodophloeus zenkeri seeds (SZS) against S. aureus MRSA4 and SA68, respectively. Antibiotic-modulating effects against more than 70% of the S. aureus strains tested were obtained when Scorodophloeus zenkeri bark (SZB) and FLS (mostly at MIC/2) were combined with chloramphenicol, tetracycline and ceftriaxone.
Conclusions: The present study demonstrated that PGS, FLS, and SZS had anti-staphylococcal effects, and that, some studied extracts and mostly FLS, and SZB could be used as antibiotic resistance modulators to fight against resistant strains of staphylococcus aureus.
