Synthesis of n-alkylated azabenzimidazoles, the base catalyzed isomerization of n-propagyl-allenyl azabenzimidazole and 1 their characterization

Abstract

N-Allyl, N-pentyl, N-propiophenone, N-benzyl, N-p-nitrobenzyl, N-3,4-dichlorobenzyl and N-propargylsubstituted 7-azabenzimidazoles were prepared through a convenient method. Under basic condition, the Npropargyl substituted azabenzimidazole isomerized to its N-allenyl substituted isomer. It is believed that the Nallenyl isolated can serve as a vital precursor for the future preparation of medicinally bioactive cycloaddition derivatives of azabenzimidazole.

Key words: Azabenzimidazoles, N-Alkylation, Propargyl, Allene, Isomerization.