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Synthesis and antibacterial activity of some quinoxalinone derivatives


F.O. Taiwo
D.A. Akinpelu
C.A. Obafemi

Abstract

Some quinoxaline derivatives 1-8 were synthesized and screened in vitro for their growth inhibitory activity against nine strains of Gram-positive and four strains of Gram-negative bacteria. Some of the compounds exhibited broad spectrum (in vitro) activity against the bacterial strains. One of the compounds, 2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-6-sulfonyl azide (6), exhibited the highest activity with an MIC value of 7.8 ìgmL-1 against four Gram-positive bacterial strains.

Keywords: Quinoxalinones, antibacterial, Gram-positive, Gram-negative.


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eISSN: 3026-8583
print ISSN: 0794-4896