Effect of alcohol and paracetamol on aspect of the hematology of albino rats

Abstract

Hemoglobin concentration (Hb), packed cell volume (PCV), white blood cell (WBC) and lymphocyte counts as well as serum cholesterol level were used to access the effects of administration of alcohol and paracetamol to albino rats. Fifteen male albino rats weighing between 75 – 160 grams were grouped into five and given various combinations of alcohol and paracetamol treatments such as 300 mgkg ^-1 paracetamol and 12% ethanol for two weeks. Thereafter, the rats were sacrificed and the various parameters determined. The Hb, PCV, WBC, Lymphocyte values were significantly lower in all the groups exposed to 12% alcohol and 300 mgkg ^-1 paracetamol. The reduction was more remarkable in rats exposed to four doses of 300 mgkg <sup>-1 and 12% ethanol compared to either control or others. The study suggests that alcohol and paracetamol ingestion could result in hematological abnormalities in albino rats.

International Journal of Natural and Applied Sciences Vol. 2(1) 2006: 16-18</sup>