Effects of smoking on the Lipoprotein levels among Mauritian of different ethnic groups and their preponderance to cardiovascular threats

Abstract

Disease progression and initiation has since long been known to be influenced by smoking and also genetic variability, owing to ethnic differences. Past studies conducted among mauritians, have reported certain genetic preponderance to diseases. In the current study, effect of smoking on various cardiovascular parameters in two different ethnic groups of Mauritius was studied. Smokers and non-smokers volunteers were recruited from ethnic Asian and African population and blood sample collected by venipuncture. Myeloperoxidase, APOA1, OxLDL, HDL, TG, LDL, and cholesterol were assessed. The level of cholesterol, TG, HDL, LDL, myeloperoxidase, APO A1, and OxLDL was 5.56±1.09, 2.13±1.70, 0.67±0.11, 4.07±0.93, 145.90±9.59, 0.42±0.13 and 74.55±13.73 mmol/L respectively in Asian smokers. Corresponding values in African smokers were respectively 4.65±0.88, 1.17±0.78, 1.18±0.42, 2.33±0.67, 172.50±15.55, 0.47±0.88 and 65.11±7.38. Results of our study indicate a significant difference (p<0.05) in cardiovascular parameters between Asian and African smokers. Furthermore, Asians were also observed to be prone to dyslipidaemia. On the other hand, smoking did not seem to influence cardiovascular parameters among African smokers, but rather seemed to have an underlying genetic protective effect against the deleterious effects of smoking.


Keywords: Smoking; Lipoproteins; Ethnic differences; Myeloperoxidase; Dyslipidaemia; Cardiovascular

Internet Journal of Medical Update Vol. 3 (2) 2008: pp. 29-35