A Study of Transdermal Delivery of Glibenclamide Using Iontophoresis

Abstract

Purpose: To assess iontophoretic transdermal delivery
of glibenclamide across pigskin for its transdermal
development. Methods: In vitro iontophoretic transdermal delivery of glibenclamide across the pigskin was investigated at three different drug concentrations in the donor cell of the diffusion apparatus, using cathodal iontophoresis (current density 0.5 mA cm-2) along with the passive controls. Results: For passive permeation, the steady state flux significantly increased with the donor drug concentration. At all concentration levels, iontophoresis considerably increased the permeation rate compared to passive controls. Flux enhancement was highest at the lowest drug load and lowest at the highest drug load. The highest flux value obtained was 0.0603 μmol cm-2 h-1 and the target flux for glibenclamide was
0.3933 μmol h-1. Required permeation rate was
achieved by iontophoresis using a much smaller
application area. Conclusion: Permeation rate of drugs across the pigskin can be considerably enhanced by the use of Iontophoresis.

Keywords: Glibenclamide; Iontophoresis; Pigskin;
Transdermal drug delivery.