Gastroretentive drug delivery systems: a patent perspective

Abstract

Patent, once seen as a technical matter for legal experts,
has today become a central concern for governments,
businesses, civil society, scientists and innovators. In a
world where the economic growth of nations is driven
increasingly by creativity and knowledge of their people,
effective intellectual property (IP) systems, which create
incentives for innovation and structures for sharing the
results, are key to unlocking the human potentials. Recent
pharmaceutical patented literature has shown increased
interest in novel dosage forms that can be retained in the
stomach for a prolonged and predictable period of time.
Since the last three decades many drug molecules
formulated as Gastroretentive Drug Delivery System
(GRDDS) have been patented keeping in view its
commercial success. This review on GRDDS attempts to
compile the available patented literature with all the
possible mechanisms used to achieve gastric retention.

Keywords: Gastric Retention, Mechanism, Patents,
Drugs, Polymers, Evaluation Method.