Main Article Content
Comparative determination of chlorpromazine hydrochloride content in multi-sourced chlorpromazine tablets in Nigeria
Abstract
content was carried using non-aqueous titrimetric and
spectrophotometric methods. Glacial acetic acid and acetone were used as the non-aqueous solvent and equivalence points were determined using visual indicators and potentiometer. Results: The results obtained showed that all the brands analyzed met the specification of the British Pharmacopoeia and so contain acceptable amounts of chlorpromazine drug content thus enabling possible brand substitution. Statistical comparison showed no significant difference between
the results obtained by determining end-point using
visual indicators and the potentiometer. Conclusion: The use of the visual indicator method is recommended
for fast and accurate routine laboratory analytical work especially in developing nations.
Keywords: Chlorpromazine, non-aqueous titration, spectrophotometric determination, potentiometry