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Effect of Orally Administered Zingiber Officinale on the Intra Ocular Pressure of Experimental Rabbits
Abstract
PURPOSE: To determine the therapeutic effect of Ginger
(Zingiber officinale) on increased intraocular pressure (IOP).
METHODS: Twenty male and female New Zealand rabbits
divided into 5 groups (A, B, C, D and E) were used. Groups B
and D were administered with topical atropine 1% for 2 weeks
while groups A and C were not so treated and group E was
used as control. After increased IOP was achieved in groups
B and D, oral ginger (1.00 ml) obtained by hot (100 oC)
extraction was administered to each rabbit in groups A and B
while 1.0 ml of cold (37 oC) extracts of ginger was
administered to groups C and D all twice daily.
RESULTS: There was significant decrease in mean IOP
(within the range of 3.0 ± 1.0 mmHg daily which finally
stabilized at 7.00 ± 1.0 mmHg) in all groups treated with both
hot and cold extracts of ginger.
CONCLUSION: Ginger lowers IOP in rabbits’ eyes and may
be a useful agent in reducing IOP in humans as it is cheap,
commonly available, relatively free from adverse effects and
beneficial to all the major tissues of the body.
eywords: Intraocular pressure, Ginger, Zingiber officinale,
Topical application
(Zingiber officinale) on increased intraocular pressure (IOP).
METHODS: Twenty male and female New Zealand rabbits
divided into 5 groups (A, B, C, D and E) were used. Groups B
and D were administered with topical atropine 1% for 2 weeks
while groups A and C were not so treated and group E was
used as control. After increased IOP was achieved in groups
B and D, oral ginger (1.00 ml) obtained by hot (100 oC)
extraction was administered to each rabbit in groups A and B
while 1.0 ml of cold (37 oC) extracts of ginger was
administered to groups C and D all twice daily.
RESULTS: There was significant decrease in mean IOP
(within the range of 3.0 ± 1.0 mmHg daily which finally
stabilized at 7.00 ± 1.0 mmHg) in all groups treated with both
hot and cold extracts of ginger.
CONCLUSION: Ginger lowers IOP in rabbits’ eyes and may
be a useful agent in reducing IOP in humans as it is cheap,
commonly available, relatively free from adverse effects and
beneficial to all the major tissues of the body.
eywords: Intraocular pressure, Ginger, Zingiber officinale,
Topical application
