Dissolution Enhancement of Drugs. Part II: Effect of Carriers

Abstract

Recent high throughput screening and combinatorial and
parallel synthesis are increasing the number of drug
molecules which are highly lipophilic. The oral route is the
most preferred route of drug administration due to its
convenience, good patient compliance and low medicine
production costs. The challenges to formulation scientists
have tremendously increased due to the pressure of
formulating these lipophilic drugs into oral drug delivery
systems. Reports in patent and scientific literature are also
increasing day by day which shows the interest of industrial
and academic research in dissolution enhancement of poorly
water soluble drugs. Part I [Int J Health Res, Jun 2009;
2(2):107-124] of this review was a technological overview on
various dissolution enhancement techniques for poorly water
soluble drugs and role of few water soluble carriers, viz.
polymers, superdisintegrants and surfactants, in dissolution
enhancement. This part describes the use of cyclodextrin,
carbohydrates, hydrotropes, polyglocolized glycerides,
dendrimers, acids and miscellaneous carriers in enhancing
dissolution of drugs.

Keywords: Dissolution enhancement; aqueous solubility, water soluble carriers; lipophilic, excipients.