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Published:
Jul 13, 2015Keywords:
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International Journal of Herbs and Pharmacological Research is an Open Access Journal under Creative Commons Licensing regulations. Thus, all articles published in IHJPR are categorised as CC-BY licensed. Inquiries above should be sent to the publisher at the address given as follows: Anthonio Research Publications, Anthonio Research Center, Anthonio Services Nigeria, P. O. Box. 960, Ekpoma, Edo State, Nigeria. OR E-mail: anthoservpub@yahoo.com
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Median lethal dose (LD50) evaluation of some polyherbal formulations marketed in northern Nigeria
Abstract
The polyherbal preparations reported here are traditionally used in Northern Nigeria for the treatment of wide range of illnesses. The aim of this study was to evaluate the acute toxicity potential of 70% ethanol extracts of forty polyherbal products by determining their median lethal dose (LD50) estimates intraperitoneally and orally using the Lorke’s method in mice. Overall 90% of the extracts indicated values that were either less toxic or slightly toxic intraperitoneally, while 10 % had values that were practically non toxic using the same route. Oral administration of the extracts showed that 25% had values that were only slightly toxic while 75 % of the herbal products had median lethal dose values that were practically non toxic. From our results this could imply that most of the extracts tested may be safe for oral use and this could explain the continuous use of the polyherbal preparations by the local people in traditional management of various ailments in the Northern part of Nigeria.
Keywords: Herbal products, AcuteToxicity, Lorke’s method, Northern Nigeria
