The Effect of Alcohol Intoxications on Hematological Parameters of Adult Albino Wistar Rats

Abstract

Due to the accessibility of alcohol, people around the world become readily intoxicated with it and in turn, it produces protease devastating effects in the human system. This study investigates the hematological effects of alcohol in albino rats grouped into three (A, B and C). Group A and B served as test while C served as control. For 14 days, 3ml/kg and 9 ml/kg of alcohol was administered to group A and B respectively. At the end of the experiment, blood samples were collected from the rats, and the changes in PCV, RBC, Hb, platelets, WBC, and differential counts, were accessed. The results showed no significant (P >0.05) increase in Hb, RBC count, WBC count, but a significant decrease (P <0.05) in platelet count of group B rats. Similarly, there was no significant increase in Hb, but a significant increase in PCV (P<0.05) of group A rats when compared with the control. The results suggest therefore, that chronic ingestion of alcohol in a dose dependent fashion, can induce hematoxicity and hence the need to curb excessive consumption of alcohol.

Keywords: Haematology, Bone marrow, Alcohol, Platelet.