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Effects of methanol extract of bark of Bauhinea purpurea on alcohol-induced liver toxicity in albino rats
Abstract
The present study has been aimed to evaluate the protective potential of methanol bark extract of Bauhinia purpurea (MBP) in albino rats against alcohol-induced hepatotoxicity. Rats were randomly divided
into four groups; alcohol control group (AC) receiving alcohol (5 g/kg), normal control group (NC) that received distilled water, and two experimental groups (E1 and E2) that were administered two doses of methanol extract (50 and 100 mg/kg body weight) for 30 days. At the end of the experiment, rats were killed after ether anesthesia and liver and blood were collected for biochemical measurements. Parameters measured were thiobarbituric acid reactive substances (TBARS), serum glutamate oxaloacetate transaminase, serum glutamate pyruvate transaminase, reduced glutathione, glutathione peroxidase, superoxide dismutase, catalase and ascorbic acid. Methanol extract inhibited lipid peroxidation as indicated low levels of thiobarbituric acid. Low levels in the activities of serum aspartate aminotransferase (AST) and serum alanine aminotransferase (ALT) in experimental animals demonstrated the protective effects of MBP from hepatic toxicity. It also maintained the levels of enzymatic and non-enzymatic antioxidants in dose dependant manner.
into four groups; alcohol control group (AC) receiving alcohol (5 g/kg), normal control group (NC) that received distilled water, and two experimental groups (E1 and E2) that were administered two doses of methanol extract (50 and 100 mg/kg body weight) for 30 days. At the end of the experiment, rats were killed after ether anesthesia and liver and blood were collected for biochemical measurements. Parameters measured were thiobarbituric acid reactive substances (TBARS), serum glutamate oxaloacetate transaminase, serum glutamate pyruvate transaminase, reduced glutathione, glutathione peroxidase, superoxide dismutase, catalase and ascorbic acid. Methanol extract inhibited lipid peroxidation as indicated low levels of thiobarbituric acid. Low levels in the activities of serum aspartate aminotransferase (AST) and serum alanine aminotransferase (ALT) in experimental animals demonstrated the protective effects of MBP from hepatic toxicity. It also maintained the levels of enzymatic and non-enzymatic antioxidants in dose dependant manner.
