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Pattern of serum transaminases in enteric fever patients attending Ebonyi State University Teaching Hospital, Abakaliki
Abstract
Enteric fever has been associated with adverse multiple-organs perturbation with the liver proposed to be most remarkably affected. In this study, the influence of enteric fever on transaminases [aspartate
transaminase (AST), and alanine transaminase (ALT)] was studied using a total of 116 subjects comprising of 55 enteric fever patients (age=27.19 ± 8.05 years) and 61 (age=26.3 ± 7.44 years) apparently healthy control
individuals. The enzyme activities were measured spectrophotometrically by Reitman-Frankel Methodology. The result showed that the level of aspartate transaminases in the typhoid patients was 41.56 ± 18.67 U/l, and significantly higher (P<0.05) than that (23.2 ± 13.07 U/l) of the healthy controls, while the patient’s alanine transaminases activity was 20.89 ± 9.25 U/l and as well higher (P<0.05) than 7.06 ± 3.54 U/l for the controls. An evaluation of gender related difference in the activities of the transaminases between enteric fever patients and the controls as well showed the activity of aspartate transaminase to be higher (P<0.05) in male (n=30, 36.57 ± 19.8 U/l) and female (n=25, 47.56 ± 15.52 U/l) patients than in the controls males (n=26, 26.61 ± 14.79 U/l) and females (n=35, 20.7 ± 11.18 U/l), while alanine transaminase was as well higher (P<0.05) in male (23.43 ± 11.57 U/l) and female (17.84 ± 3.64 U/l) patients than in healthy control males (6.48 ± 3.37 U/l) and
females (7.49 ± 3.66 U/l). We opine that transaminases might be accessible markers of hepatic involvement in enteric fever, its estimation should be widely adopted in the diagnostic and prognostic management of affected patients.
transaminase (AST), and alanine transaminase (ALT)] was studied using a total of 116 subjects comprising of 55 enteric fever patients (age=27.19 ± 8.05 years) and 61 (age=26.3 ± 7.44 years) apparently healthy control
individuals. The enzyme activities were measured spectrophotometrically by Reitman-Frankel Methodology. The result showed that the level of aspartate transaminases in the typhoid patients was 41.56 ± 18.67 U/l, and significantly higher (P<0.05) than that (23.2 ± 13.07 U/l) of the healthy controls, while the patient’s alanine transaminases activity was 20.89 ± 9.25 U/l and as well higher (P<0.05) than 7.06 ± 3.54 U/l for the controls. An evaluation of gender related difference in the activities of the transaminases between enteric fever patients and the controls as well showed the activity of aspartate transaminase to be higher (P<0.05) in male (n=30, 36.57 ± 19.8 U/l) and female (n=25, 47.56 ± 15.52 U/l) patients than in the controls males (n=26, 26.61 ± 14.79 U/l) and females (n=35, 20.7 ± 11.18 U/l), while alanine transaminase was as well higher (P<0.05) in male (23.43 ± 11.57 U/l) and female (17.84 ± 3.64 U/l) patients than in healthy control males (6.48 ± 3.37 U/l) and
females (7.49 ± 3.66 U/l). We opine that transaminases might be accessible markers of hepatic involvement in enteric fever, its estimation should be widely adopted in the diagnostic and prognostic management of affected patients.
