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CD4+ T-cells count in HIV-malaria co-infection in adult population in Nnewi, South Eastern Nigeria
Abstract
The study was designed to evaluate CD4+ T-cells count in subjects with HIV-malaria co-infection in Nnewi, South Eastern Nigeria and to assess the effects any changes in CD4+ counts has on the prevalence and
or severity of both illness. Two hundred and eighty-five participants aged between 16 and 72 years were recruited for the study and grouped as symptomatic HIV subjects, asymptomatic HIV subjects, HIV/AIDS
subjects on ART (Antiretroviral Therapy) and HIV-seronegative subjects. HIV and malaria parasite screening, CD4+ T-cell count and parasite density were determined using standard laboratory methods. The result showed that the prevalence of malaria infection was 75% in symptomatic HIV, 46.7% in asymptomatic HIV and 59.6% in HIV/AIDS subjects on ART respectively as opposed to 26.9% observed in the control (P<0.001). The CD4+ T-cell count was significantly lower in both symptomatic and asymptomatic HIV-malaria infected subjects when compared with the malaria-infected control subjects (238 ± 176, 312 ± 144, P<0.01) respectively. CD4+T-cells count was also significantly lower in malaria-infected HIV/AIDS on ART when compared to the malaria-infected control subjects (315 ± 195, P<0.01). The study concludes that malaria prevalence is increased in subjects with HIV/malaria co-infection and is accompanied by a significant reduction in CD4+T-cell counts,
which might worsen the severity and prognosis in these subjects. Other public health implications are discussed.
or severity of both illness. Two hundred and eighty-five participants aged between 16 and 72 years were recruited for the study and grouped as symptomatic HIV subjects, asymptomatic HIV subjects, HIV/AIDS
subjects on ART (Antiretroviral Therapy) and HIV-seronegative subjects. HIV and malaria parasite screening, CD4+ T-cell count and parasite density were determined using standard laboratory methods. The result showed that the prevalence of malaria infection was 75% in symptomatic HIV, 46.7% in asymptomatic HIV and 59.6% in HIV/AIDS subjects on ART respectively as opposed to 26.9% observed in the control (P<0.001). The CD4+ T-cell count was significantly lower in both symptomatic and asymptomatic HIV-malaria infected subjects when compared with the malaria-infected control subjects (238 ± 176, 312 ± 144, P<0.01) respectively. CD4+T-cells count was also significantly lower in malaria-infected HIV/AIDS on ART when compared to the malaria-infected control subjects (315 ± 195, P<0.01). The study concludes that malaria prevalence is increased in subjects with HIV/malaria co-infection and is accompanied by a significant reduction in CD4+T-cell counts,
which might worsen the severity and prognosis in these subjects. Other public health implications are discussed.
