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Synthesis and biological studies of Co(II) and Cd(II) 5-(3,4,5- trimethoxybenzyl) pyrimidine-2,4-diamine (Trimethoprim) complexes
Abstract
Two metal complexes of Co(II) and Cd(II) 5-(3,4,5-trimethoxybenzyl) pyrimidine-2,4-diamine (Trimethoprim) were synthesized and characterized by both analytical and spectroscopic methods. They are 4-coordinate complex containing two molecules of 5-(3,4,5-trimethoxybenzyl) pyrimidine-2,4-diamine (TMP) and two chloride ions. A distorted tetrahedral geometry is suggested for their structure, where TMP behaves as a monodentate ligand. The metal binds through the pyrimidine N(1) of the ligand. The complexes have been screened for antiplasmodial activity against Plasmodium berghei and the results show that they are less active than the parent ligand. Toxicological study was carried out by investigating the effect of administration of the complexes on alkaline phosphatase activity of kidney, liver and serum of albino rats and they are found to be nontoxic.
