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Serum lipid profile and lipid pro-atherogenic indices of a cohort of Nigerian adults with varying glycemic and blood pressure phenotypes
Abstract
Dyslipidemia is common in patients with Type 2 diabetes and those with hypertension. The lipid profile and lipid pro-atherogenic indices of subjects with varying levels of fasting blood glucose and blood pressures
may be different and thus was studied. Standard clinical and anthropometric methods were used to determine/measure all necessary parameters. Data from 189 subjects (90 males), aged 22-84 years, who met the inclusion criteria were analyzed. Five glycemic/blood pressure phenotypes were defined, namely: hypoglycemic and normotensive (HN), hypoglycemic and hypertensive (HH), normoglycemic and hypertensive (NH), diabetic and normotensive (DN), and diabetic and hypertensive (DH) and their data compared to the control (normoglycemic and normotensive) group. Hypertensive subjects, irrespective of their fasting blood glucose levels had the worst lipid profile and had higher serum lipid pro-atherogenic indices compared to normotensive subjects. These lipid abnormalities were more prevalent within the older (.45 years
old) and the overweight/obese subjects irrespective of sex. The lipid profile of hypertensive subjects should be monitored regularly and adjusted medically if necessary, irrespective of their fasting blood glucose level.
Management of diabetes and hypertension (especially in this environment) should apart from targeting lipid abnormalities, emphasize therapeutic lifestyle changes that encourage weight loss.
may be different and thus was studied. Standard clinical and anthropometric methods were used to determine/measure all necessary parameters. Data from 189 subjects (90 males), aged 22-84 years, who met the inclusion criteria were analyzed. Five glycemic/blood pressure phenotypes were defined, namely: hypoglycemic and normotensive (HN), hypoglycemic and hypertensive (HH), normoglycemic and hypertensive (NH), diabetic and normotensive (DN), and diabetic and hypertensive (DH) and their data compared to the control (normoglycemic and normotensive) group. Hypertensive subjects, irrespective of their fasting blood glucose levels had the worst lipid profile and had higher serum lipid pro-atherogenic indices compared to normotensive subjects. These lipid abnormalities were more prevalent within the older (.45 years
old) and the overweight/obese subjects irrespective of sex. The lipid profile of hypertensive subjects should be monitored regularly and adjusted medically if necessary, irrespective of their fasting blood glucose level.
Management of diabetes and hypertension (especially in this environment) should apart from targeting lipid abnormalities, emphasize therapeutic lifestyle changes that encourage weight loss.
