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Effect of dietary incorporation of Vernonia colorata (Willd) leaves on blood lipid profile of albino rats
Abstract
The effect of 5 and 10% dietary incorporation of leaves of Vernonia colorata on serum triacyglycerol, cholesterol, high density lipoproteins (HDL), low density lipoproteins (LDL) and very low density lipoproteins (VLDL) was studied in albino rats. Processed and unprocessed leaves of Vernonia colorata (PVC and UPVC) were incorporated into standard Vital feed at 5 and 10% levels and fed to adult male wistar rats weighing 90-
160g over a period of 28 days. Feeding of processed and unprocessed Vernonia colorata resulted in significant (P≤0.05) decreases in serum triacylglycerol concentration (mg/100ml) in groups fed with 5% PVC (133.91±2.09), 10% PVC (110.39±2.57), 5% UPVC (153.74±1.64) and 10% UPVC (111.41±2.30) relative to the control (159.15±0.32) fed with the basal diet without the vegetable. Serum cholesterol concentration (mg/100 ml) also decreased significantly in groups fed 5% PVC (178.07±3.46), 10% PVC (174.60±4.21), and 10% UPVC (148.77±1.88) relative to the control (195.31±4.39). Serum HDL concentrations increased
significantly in groups fed 5% PVC (106.02±2.05), 10% PVC 120.15±2.65), 5% UPVC (87.06±2.47), and 10% UPVC (103.33±2.61) relative to the control (61.79±0.65). Serum LDL concentration decreased
significantly in groups fed 5% PVC (45.27±2.10), 10% PVC (32.38±3.67), 5% UPVC (73.73±3.07) and 10% UPVC (23.16±2.49) relative to control (101.69±3.66). Serum VLDL Concentrations decreased significantly in groups fed 5% PVC (26.78±0.42), 10% PVC (22.08±0.51), 5% UPVC (30.75±0.33) and 10% UPVC (22.28±0.46) relative to control (31.83±0.06). Feeding of Vernonia colorata at 10% level of dietary incorporation in the unprocessed form resulted in a more marked decrease in serum Triacylglcerols, Cholesterol, LDL and VLDL and increase in HDL. These findings are indicative that dietary incorporation of Vernonia colorata at 10% levels in both processed and unprocessed forms could have positive modulatory effect on blood lipid profile, by increasing HDL which is beneficial while reducing blood levels of LDL, VLDL and cholesterol which are considered high risk factors for cardiovascular diseases.
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Key words: Vernonia colorata, lipids, cardiovascular diseases, albino rats.
