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Antineoplastic activity of N–salicylideneglycinato–di–aquanickel(II) complex against Ehrlich Ascites Carcinoma (EAC) cells in mice
Abstract
In order to find out compounds having antineoplastic activities N-salicylideneglycinato-diaquanickel(II) complex was synthesized and characterized. The antitumour activity was studied against Ehrlich Ascite Carcinoma (EAC) cells in Swiss Albino mice by monitoring the parameters like tumour weight measurement, survival time of tumour bearing mice, tumour cell growth inhibition etc. Some haematological parameters such as RBC, WBC, Hb%, differencial counts (lymphocytes, neutrophill, monocytes), alkaline
phosphatase activity etc. were also measured. The results showed that Ni(II) complex has positive effect against EAC cells. This assessment was done by comparing the results with those obtained with the standard drug bleomycin. The compound can be considered as an effective anticancer agent.
Keywords: Antineoplastic activity, N-salicylideneglycinato-di-aquanickel(II) (SGN), EAC, and ALP.
Int. J. Biol. Chem. Sci. Vol. 2 (3) 2008: pp. 292-298
