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In vivo antiplasmodial activity of ZS-2A: a fraction from chloroform extract of Zizyphus spina-christi root bark against Plasmodium berghei berghei in mice


B Adzu
A K Haruna
O A Salawu
U D Katsayal
A Njan

Abstract



Zizyphus spina-christi is used in ethnomedical practice for the treatment of fever. Bio-assay guided investigation of the plant's root bark was initiated and ZS-2A, a fraction from the chloroform extract of the material, eluted with hexane-ethylacetate (50:50) using flash column chromatography, was evaluated for in vivo antiplasmodial activity against Plasmodium berghei in mice. Four-day suppressive, curative effect against established infection and prophylactic models of antiplasmodial studies were used. The fraction (25, 50 and 100 mg/kg, p.o.) showed a potent activity against the parasite in the suppressive and curative tests. The result suggests that ZS-2A may be a promising agent for malaria treatment.

Keywords: Fraction ZS-2A, Zizyphus spina-christi, Plasmodium berghei berghei.

International Journal of Biological and Chemical Sciences Vol. 1 (3) 2007: pp. 281-286

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eISSN: 1997-342X
print ISSN: 1991-8631