Nature and properties of carbohydrate derivatives of piperidin-4-one

Abstract

In the modern world, drug resistance of pathogens responsible for various diseases has become a deadly threat to mankind, and  requires the search for new biologically active substances. One of the approaches is the introduction of carbohydrates with unprotected  hydroxyl groups into the structure of medical drugs, which can reduce their toxicity, increase their water solubility and increase the  selectivity of action. The aim of the study was to develop a scientific basis for the synthesis of biologically active substances by  condensation of glycosylvinylnitrosourea with various γ-piperidone derivatives and to study their properties. The choice of γpiperidone  derivatives was justified by their strong antiviral and antibacterial activity. Despite their low water solubility, these compounds have  potential for the development of new effective drugs. Experiments were carried out using various aglycones and carbohydrate  components. A variety of methods including analytical, comparative, computer modelling and experimental methods were employed in  this work to achieve the results. The results showed potentials in the proposed synthesis methods for the development of new drug  compounds. The introduction of unprotected hydroxyl groups into the structure of the medicinal compounds by forming glycosyl  carbamide bond improved the toxicological characteristics, solubility, and selectivity. It has been shown experimentally that the  interaction of nitroso derivatives of glycosylurea with basic amines is relatively easy. This study opens prospects for the development of  new drugs with improved properties and biological activity. The results of this work may lead to the development of effective therapeutic  agents in the fight against drug resistance and infectious diseases.