Antioxidant and anti-gastroenteritis activities of Funtumia elastica (Apocynaceae) and Caesalpinia bonduc (Caeasalpiniaceae)

Abstract

Oxidative stress and infectious diseases are health problems on a global scale. The aim of this study was to evaluate the antioxidant and anti-gastroenteritis activities of hydroethanolic extracts of leaves of Funtumia elastica and Caesalpinia bonduc. After obtaining the hydroethanolic extracts, the phytochemical tests were carried out. The antioxidant activity was evaluated by different assays using 2,2-Diphenyl-1-picrylhydrazyl (DPPH) and lipid peroxidation inhibition (FTC and TBARS methods). The agar well diffusion method was used to determine the antibacterial activity to the plant extract. The triphytochemical study has revealed that these plants extracts contain a diversity of secondary metabolites. F. elastica gave a good anti-radical activity (IC₅₀ = 36 μg/ml). F. elastica recorded the highest rate of inhibition of lipid peroxidation with 63% (FTC method) and 65% (TBARS method). C. bonduc extract (200 mg/ml) inhibited the in vitro growth of all the bacterial strains studied in this study with inhibition diameters that evolved between 9 mm and 13 mm. These plant extracts could be used if they are improved for the treatment of gastroenteritis related to Shigella and Escherichia coli and in the care of pathologies related to oxidative stress.

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Keywords: Antioxidant, anti-gastroenteritis, Funtumia elastica, Caesalpinia bonduc, hydroethanolic extracts