A multi-drug resistance pattern of a Leclercia adecarboxylata strain isolated from a urinary tract infection of a patient at China-Guinea friendship hospital of Kipé/Conakry

Abstract

Leclercia adecarboxylata (LAD) is a member of Enterobacteriaceae family that is usually reported as an opportunistic human pathogen. A few reports have described resistant strains in the literature. The aim of this paper was to describe the antimicrobial resistance pattern of a LAD strain isolated from a urinary tract infection in a 39-year-old immunocompetent man. The bacterial identification and antibiotic sensitivity tests were performed on Vitek 2 Compact 15. The results revealed the presence of LAD with a particular multidrug resistance pattern. It was sensitive only to imipenem (=1 μg/ml), and totally resistant to association of trimethoprim/sulfamethoxazole (≥320 μg/ml), ticarcillin (≥128 μg/ml), nitrofurantoin (=128 μg/ml), cefalothin (≥64 μg/ml), cefoxitin (≥64 μg/ml), cefotaxime (≥64 μg/ml), ceftazidime (≥64 μg/ml), amikacin (≥64 μg/ml), ampicillin (≥32 μg/ml), nalidxic acid (≥32 μg/ml), and a combination of amoxicillin/clavulanic acid (≥32 μg/ml), gentamicin (≥16 μg/ml), tobramycin (≥16 μg/ml), ofloxacin (≥8 μg/ml), and ciprofloxacin (≥4 μg/ml). It showed the intermediate sensitivity to the association of piperacillin/tazobactam (=64 μg/ml), and ertapenem (=4 μg/ml). The findings showed that this isolate of LAD had a multidrug resistance pattern to almost all the antibiotics tested (except imipenem). This suggests that LAD could be considered as an emergent bacterial pathogen capable of causing infections in human and carrying multidrug resistance pattern to numerous antibiotic families in Guinea.

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Keywords: Leclercia adecarboxylata, multi-drug, resistance, Kipé/Conakry