Antioxidant and Anticancer activities of yeast grown on commercial media

Abstract

The use of Synthetic antioxidants is being widely restricted because of their reported toxic and carcinogenic effects. Thus, now there is considerable interest being focused towards finding antioxidants from natural sources with any unlikely effects. There is also considerable evidence which indicates lower risk of Cancer in yeast extracts and the used commercial media. The present study was conducted to determine antioxidant activity of yeast extracts grown on four different commercial media using DPPH, total phenolic content, total antioxidant activity and TBARS and to study the anticancer activity of yeast extracts on the mentioned media against human hepato carcinoma cell line (HEPG-2) using the MTT assay, Cell Cycle Analysis and mRNA Expression of Cell Apoptosis-related Gene. The yeast extract of corn meal was found to have more antioxidant activity than other commercial media. The antioxidant potential was then correlated with the total phenol content. The yeast extract of corn meal showed maximum anticancer activity against HEPG-2 as compared to that of other used media. Overall, the results achieved in this study are promising and indicate that yeast fermentation on corn meal medium is better than other used media to get on antioxidant and anticancer activities.

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Keywords: Yeast, commercial media, Antioxidant, Anticancer activity