Article Sidebar
Keywords:
Article Details
Submission of a paper for publication implies the transfer of the copyright from the author(s) to the publisher upon acceptance. International Formulae Group is therefore the copyright holder after publication of an article in International Journal of Biological and Chemical Sciences, and published articles should not be used for commercial purpose without the written consent of the Editor-in-Chief. They are licensed under a Creative Commons Attribution-Non Commercial-Share Alike 4.0 International License.
Main Article Content
Glucose lowering activities of mombintane I and mombintane II isolated from the leaves of Spondias mombin L
Abstract
The uses of Spondias mombin Linn in folk medicine as part of recipe for the management and treatment of Diabetes mellitus are well documented. This has been investigated and proven using various experimental models. The aim of this study was to report two isolated compounds from S. mombin leaves probably exhibiting synergistic glucose lowering effects in the in vitro model. The in vitro α-amylase inhibitory assay was used to establish the glucose lowering activities of the isolated compounds while, the isolated compounds were determined from the spectra of their MS, IR and proton NMR. It was established that they are sterols with molecular formula C29H52O2 and C29H50O. The two compounds exhibited a synergistic effect of 61% α- amylase inhibitory activity. This study shows that mombintane I and mombintane II exhibit synergistic effect in lowering blood glucose levels.
Keywords: Mombintane I, Mombintane II, Glucose lowering, Spondias mombin, Leaves.
