Article Sidebar
Published:
Feb 8, 2016Keywords:
Article Details
Submission of a paper for publication implies the transfer of the copyright from the author(s) to the publisher upon acceptance. International Formulae Group is therefore the copyright holder after publication of an article in International Journal of Biological and Chemical Sciences, and published articles should not be used for commercial purpose without the written consent of the Editor-in-Chief. They are licensed under a Creative Commons Attribution-Non Commercial-Share Alike 4.0 International License.
Main Article Content
Some physiochemical changes associated with type 2 diabetes mellitus in Benin City, Nigeria
Abstract
The present study was designed to determine the level of malondialdehyde (MDA) concentration, serum c reactive protein (CRP) and CD4+ T cells in type 2 diabetes mellitus in a view to assessing the complications associated with the non specific activation of CD4+ T cells. A total of 80 subjects aged between 18 and 50 years gave their consent to participate in the study. They consist of 40 known type 2 diabetes mellitus and 40 aged matched apparently healthy control subjects on routine checkup. Malondialdehyde concentration was determined by spectrophotometric method. Serum c reactive protein was determined by enzyme-linked immunosorbent assay method. CD4+ T cells were estimated using Partec cyflow counter. There was a significant increase in MDA concentration, CRP and CD4+ T cells in type 2 diabetes mellitus subjects when compared with the aged matched control group (P < 0.05). Type 2 diabetes mellitus causes an increased production of free radicals which is possibly linked to the complications associated with non specific activation of CD4+ T cells.
© 2015 International Formulae Group. All rights reserved.
Keywords: Free radicals, CD4+ T cells, diabetes mellitus, cytokines, c reactive protein, malondialdehyde
