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Efficiency assessment of trypanocidal treatments in the research station of Avetonou in Togo
Abstract
In Togo as elsewhere, among the animal trypanosomosis control strategies, the chemotherapy constitutes the most used method. In order to assess the efficiency of two trypanocidal drugs (isometamidium chloride and diminazene) on cattle, a longitudinal study was conducted from September to November 2011 in the research station of Avetonou located in the Prefecture of Agou in Togo. A parasitological survey was carried out on two groups of 90 cattle each (for a total of 180 cattle) using the buffy coat technique at regular intervals of two weeks over a total period of 56 days. The animals of the first group were treated with isometamidium chloride (0.5 mg/kg) and the second group (untreated animals) was used as a control group. The comparison of the incidence of trypanosomosis between the two groups was performed using three statistical tests: the Chisquared test, the test of risk Reduction, and the “Eisler ratio test”. These analyses revealed an inefficiency of the preventive treatment with isometamidium chloride at the dose of 0.5 mg/kg bodyweight contrarily to the curative treatment that was effective. For diminazene, used at a dose of 3.5 mg/kg bodyweight, strains of Trypanosoma vivax and Trypanosoma congolense were not eliminated in 14.29% of cases.
Keyswords: Trypanocidal treatment, isometamidium, diminazene, Avétonou, Togo.
