Hepatoprotective role of Moringa oleifera ethanolic leaf extract on Liver functions (Biomarker) in cadmium chloride induced hepatotoxicity in Albino wistar rats

Abstract

This study investigated the hepatoprotective role of ethanolic extract of Moringa oliefera (M.O) on liver function (Biomarkers) in cadmium chloride (CdCl₂)-induced hepatotoxicity on the liver of albino Wistar rats. Sixty-six adult male albino wistar rats weighing between 130g – 180g were used. LD₅₀ was determined for both CdCl₂and MO using twenty-six (26) rats, while 40 rats were used for the experiment proper. The experimental rats were distributed into eight groups –A (control) and B, C, D, E, F, G and H, served as the treatment groups that received graded doses of CdCl₂or MOor both simultaneously or at separate periods. The animals were then euthanized for sample collection and analysis using standard methods. The results showed significant increase (P<0.05) in the serum levels of Alanine aminotransferase (ALT) (430.50 ± 149.20), Aspartate aminotransferase (AST) (421.10 ± 8.34) and Alkaline Phosphatase (ALP) (515.60 ± 21.78) of animals in group B, but some protective effect of MO in the treatment groups with significant decreases in ALT, AST and ALP levels. The study therefore concludes that ethanolic extract of Moringa oleifera showed appreciable hepatoprotective values on liver functions (biomarkers) in CdCl₂hepatotoxicity.

Key words: Liver Functions, Cadmium, Moringa oleifera, Hepatoprotective, Hepatotoxiciy