Comparative Study on Liver Enzymes Activity and Blood Group Variations

Abstract

The aim of this study is to determine the activities of some selected liver enzymes amongst apparently healthy subjects of different blood groups. The study involved 95 apparently healthy students of Ambrose Alli University, Ekpoma, Edo State, Nigeria, between the ages of 18-30, and distributed as follows; blood group O (30), group AB (18), group A (22) and blood group B (25). Blood samples were collected from the antecubital vein and separated to obtain serum. The activities of Alkaline phosphatase (ALP), Aspartate amino transferase (AST) and Alanine amino transferase (ALT) in the serum were determined using the spectrophometric method and the results were compared using SPSS (version 15). The results showed that the activities of AST and ALT were not significantly different (p>0.05) among the blood groups. However, the activity of ALP was significantly different (p<0.05) from those of blood group A, AB and O. Based on the findings of this study therefore, ABO blood group variations may have an influence on some liver enzymes activity.

Keywords: ABO Blood Groups, Liver enzymes, Liver function