Effects of Septrin Administration on Blood Cells Parameters in Humans

Abstract

The hematological changes associated with septrin administration in humans were investigated. One hundred (100) male patients (aged 18-40 years) who were placed on the therapeutic dose of septrin were divided into four groups based on the prescribed duration of their septrin intake. Twenty (20) healthy males served as the control. At the end of the treatment period, blood was obtained from each subject for the estimation of blood parameters following standard procedures. The results showed that the packed cell volume (PCV), total white blood cell count (WBC), neutrophils and platelets were significantly decreased (p<0.05), especially after 7-10 days of septrin administration, compared to the control values. On the other hand, the reticulocytes, lymphocytes, eosinophils and prothrombin time (PT) showed significant increases (p<0.05), compared to the value for the control. The observed changes in blood parameters in this study were all duration-dependent. It is concluded that septrin administration can cause alterations in blood parameters, and these duration-dependent changes should be put into consideration when recommending its intake.

Key words: Septrin, Hematological parameters, Humans, Therapeutic dose