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Serum lipid profile in diabetic and hypertensive Nigerian subjects from Kano metropolis-Nigeria
Abstract
Aim: This study was undertaken to compare the serum lipid profile of diabetic and hypertensive subjects resident in Kano metropolis and to evaluate their pattern and probable disposition to atherosclerosis and coronary heart disease.
Methods: Forty hypertensive subjects (HPT, 20 males and 20 females) and fifty non-insulin dependent diabetic subjects (DBT, 29 males and 21 females) had their lipid levels, blood pressures (BP) and body mass index (BMI) compared.
Results: Hypertensive subjects had higher mean serum TC, HDL-CH, BMI and BP values that diabetic subjects. Male/HPT subjects had higher mean serum TC, HDL-CH, LDL-CH and BP values than their female counterparts. Female diabetics had higher mean serum TC, LDL-CH and BMI values than their male counterparts. In both HPT and DBT subjects, there were correlations between TC and LDL and between TG and VLDL. Treatment with antihypertensive and antidiabetic drugs produced significant differences in mean serum HDL-CH (P < 0.005) and LDL-CH (P < 0.025) between HPT and DBT subjects.
Conclusion: From the study, Diabetes seems to increase the TC: HDL-CH ratio in the study subjects suggesting a greater risk of developing coronary heart disease. High BMI values were also observed which is consistent with earlier reports that link obesity with increased risk of non-insulin dependent diabetes mellitus.
Highland Medical Research Journal Vol. 4(1) 2006: 31-38
Methods: Forty hypertensive subjects (HPT, 20 males and 20 females) and fifty non-insulin dependent diabetic subjects (DBT, 29 males and 21 females) had their lipid levels, blood pressures (BP) and body mass index (BMI) compared.
Results: Hypertensive subjects had higher mean serum TC, HDL-CH, BMI and BP values that diabetic subjects. Male/HPT subjects had higher mean serum TC, HDL-CH, LDL-CH and BP values than their female counterparts. Female diabetics had higher mean serum TC, LDL-CH and BMI values than their male counterparts. In both HPT and DBT subjects, there were correlations between TC and LDL and between TG and VLDL. Treatment with antihypertensive and antidiabetic drugs produced significant differences in mean serum HDL-CH (P < 0.005) and LDL-CH (P < 0.025) between HPT and DBT subjects.
Conclusion: From the study, Diabetes seems to increase the TC: HDL-CH ratio in the study subjects suggesting a greater risk of developing coronary heart disease. High BMI values were also observed which is consistent with earlier reports that link obesity with increased risk of non-insulin dependent diabetes mellitus.
Highland Medical Research Journal Vol. 4(1) 2006: 31-38
