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May 12, 2005Keywords:
cholesterol. LDL HDL lipid rations homocysteine pregnant and CVD risk factors
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Serum Lipid Profiles, Homocysteine Levels And Cardiovascular Disease Risk In Pregnant Nigerian Women
Abstract
Objectives: To compare the levels of lipids and homocysteine in the serum of third- trimester pregnant women and health , age –matched non pregnant controls.
Methods: We compared the levels of these lipids {total cholesterol, particularly lipoproteins such as LDL} and homocysteine in the serum of third- trimester pregnant women healthy, age –matched non –pregnant controls. Blood samples were obtained by venipuncture and the samples were allowed to clot at room temperature for 45 minutes before centrifugation to separate the serum.
Result: Compared to the controls, the following substances were significantly elevated in the pregnant women: total cholesterol, 212vs.191mg/dL{p=0.02}; triglycerides, 153vs. 89.5 mg/dL{p=0.004};and hdL,67.0vs.56.6 mg/dL{p=.004}.the mean LDL-cholesterol levels of the pregnant {116mg/dL}and non pregnant controls{110mg/dLwere not significantly different. However, the mean homocysteine concentration of the pregnant women was about 30% lower compared with the controls group {7.1vs.10.1m01/L,p<0.001}. the mean folate levels of the pregnant women, 16/18 of whom were taking a multivitamin supplement, was more than twice that of the non –pregnant controls {10.4vs.44ng/mL, p= 0.002}, where as the vitamin B12 level was nearly two –fold higher in the controls than in the pregnant woman {620vs.343pg/mL,p=0.001}. the lower homocysteine {levels in the pregnant women relative to the non –pregnant women were likely due to the use of folate supplements by the pregnant women. Despite the difference in the serum lipic profiles of the pregnant and non - pregnant women. Both groups had values of serum concentration of lipids. Folate vitamin B12 and homocysteine that were well within the reference range of values provided by the American Heart Association {AHA}.
Conclusion: These result indicate that pregnant women in Nigeria show the same trend that most women in other parts of the world exhibit as they other the third trimester of pregnancy; that is their serum cholesterol and triglyceride levels increase. While their homocysteine levels decrease.
Key words: cholesterol. LDL, HDL, lipid rations homocysteine, pregnant, and CVD risk factors.
Highland Medical Research Journal Vol.1(2) 2002: 12-16
Methods: We compared the levels of these lipids {total cholesterol, particularly lipoproteins such as LDL} and homocysteine in the serum of third- trimester pregnant women healthy, age –matched non –pregnant controls. Blood samples were obtained by venipuncture and the samples were allowed to clot at room temperature for 45 minutes before centrifugation to separate the serum.
Result: Compared to the controls, the following substances were significantly elevated in the pregnant women: total cholesterol, 212vs.191mg/dL{p=0.02}; triglycerides, 153vs. 89.5 mg/dL{p=0.004};and hdL,67.0vs.56.6 mg/dL{p=.004}.the mean LDL-cholesterol levels of the pregnant {116mg/dL}and non pregnant controls{110mg/dLwere not significantly different. However, the mean homocysteine concentration of the pregnant women was about 30% lower compared with the controls group {7.1vs.10.1m01/L,p<0.001}. the mean folate levels of the pregnant women, 16/18 of whom were taking a multivitamin supplement, was more than twice that of the non –pregnant controls {10.4vs.44ng/mL, p= 0.002}, where as the vitamin B12 level was nearly two –fold higher in the controls than in the pregnant woman {620vs.343pg/mL,p=0.001}. the lower homocysteine {levels in the pregnant women relative to the non –pregnant women were likely due to the use of folate supplements by the pregnant women. Despite the difference in the serum lipic profiles of the pregnant and non - pregnant women. Both groups had values of serum concentration of lipids. Folate vitamin B12 and homocysteine that were well within the reference range of values provided by the American Heart Association {AHA}.
Conclusion: These result indicate that pregnant women in Nigeria show the same trend that most women in other parts of the world exhibit as they other the third trimester of pregnancy; that is their serum cholesterol and triglyceride levels increase. While their homocysteine levels decrease.
Key words: cholesterol. LDL, HDL, lipid rations homocysteine, pregnant, and CVD risk factors.
Highland Medical Research Journal Vol.1(2) 2002: 12-16
